Using the SLE-key® Rule-Out Test in Clinical Practice

SLE-key(®) rule-out serologic test for excluding the diagnosis of systemic lupus erythematosus: Developing the ImmunArray iCHIP(®).

We describe here the development, verification and validation of the SLE-key(®) rule-out test for a definitive rule-out of a diagnosis of systemic lupus erythematosus (SLE). The test uses the proprietary iCHIP(®) micro-array technology platform (Fattal et al., 2010) to identify discriminating patterns of circulating autoantibodies among SLE patients compared with self-declared healthy individua...

Key autoantigens in SLE.

Murine and human systemic lupus erythematosus (SLE, lupus) is characterized by the appearance of autoantibodies directed to nuclear and cell membrane phospholipid components. Some functionally related nucleic acid-containing macromolecules such as chromatin or ribonucleoprotein particles are specifically targeted both by autoantibodies and T cells involved in lupus pathogenesis. In the last dec...

Presentation of SLE in UK primary care using the Clinical Practice Research Datalink

OBJECTIVES To describe the presenting symptoms of SLE in primary care using the Clinical Practice Research Database (CPRD) and to calculate the time from symptom presentation to SLE diagnosis. METHODS Incident cases of SLE were identified from the CPRD between 2000 and 2012. Presenting symptoms were identified from the medical records of cases in the 5 years before diagnosis and grouped using...

How to monitor SLE in routine clinical practice.

A century ago syphilis was regarded as the great masquerader. Its modern equivalent is lupus. It may present to a wide range of specialists and its outcome, while much improved, remains uncertain in a significant number of patients.

Quantitative Dengue Test: Is it Practical for Clinical Practice?